CIPKEBIP Annual Conference 2011 Programme “ Biosynthetic and metabolic engineering in industrial drug and process development”

September 15, 2011
Jožef Stefan Institute, Jamova cesta 39, Ljubljana, Large lecture hall
09:00 – 09:30 Registration  
Chairs: Enej Kuščer, Hrvoje Petković
Conference opening  
09:30 – 10:00 Welcome greetings:

Dušan Turk, scientific director CIPKeBiP
Jadran Lenarčič, director JSI
Urban Kranjc, Ministry of Higher education, Science and Technology

10:00 – 10:45 Plenary lecture: Oxytetracycline - from discovery to genome sequence Iain S. Hunter
10:45 – 11:00 Coffee break  
11:00-13:40 Section 1 »Biosynthetic engineering and drug development«
11:00-11.30 Macrolides - more than antibiotics Vesna Eraković Haber
11:30-12:00 Towards novel modular polyketide synthases- lessons learnt from evolution John Cullum
12:00-12:10 Coffee break  
12:10-12:40 Biosynthetic Engineering Approaches to Natural Product Lead Optimization Steve Kendrew
12:40-13:10 Genomic data analysis - "What would Google do?" Daslav Hranueli
13:10-13:40 Exploring modularity - Cooperating fungal iterative polyketide synthases for resorcylic acid lactone production Istvan Molnar
13:40 – 14:40 Lunch break  
14:40-15:10 Section 2 »Presentation of centres of excellence CO ENFIST and CO BIK«
14:40-14:55 Presentation of achievements of CO ENFIST Matjaž Polak
14:55-15:10 Presentation of achievements of CO BIK Rebeka Koncilja
15:10-18:20 Section 3 »Biology of actinomycetes and industrial process development«
15:10-15:40 Manipulation of streptomycete mycelial architecture Paul Herron


Improved erythromycin A production and purity by modulation of the overexpression of tailoring genes eryK and eryG in Saccharopolyspora erythraea and their fermentation optimization Ju Chu
16:10-16:20 Coffee break  
16:20-16:50 New insights into substrate supply and regulation of FK506 Biosynthesis and their implications for Bioprocess development and drug discovery Gregor Kosec
16:50-17:20 Improvement of Oxytetracycline Production by Using Different Genetic Engineering Strategies Meijin Guo
17:20-17:50 Streptomycetes are a source of hydrolytic enzymes with potential in lipid biotransformation Dušica Vujaklija
Closure of the first day: Enej Kuščer, Hrvoje Petković  
September 16, 2011  
Jožef Stefan Institute, Jamova cesta 39, Ljubljana, Large lecture hall
09:00 – 09:30 Registration  
Chair: Dušan Turk  
9:30-14:35 Presentation of CiPKeBiP scientific work in year 2011
09:30 – 10:15 WP1: Mechanisms and pathways of immune response  
  Overview Maja Rupnik
    Tatjana Lejko
10:15 – 11:00 WP2: Intra and Intercellular communication  
10:15 – 10:24 Development of novel bioactive compounds by biosynthetic and chemobiosynthetic approaches Enej Kuščer
10:24 – 10:33 Role of cathepsins in cancerogenesis Marko Fonović
10:33 – 10:42 Super-resolution Microscopy and Cell Physiology Marko Kreft
10:42 – 10:51 Organelle mediated signaling in endocrine tissue models Marjan Slak Rupnik
10:51 – 11:00 Secreted Phospholipases A2 and Breast Cancer Jože Pungerčar
11:00 – 11.15 Coffee break  
11:15 – 12:35 WP3: Adaptation mechanisms of extremofiles to environment  
  Overview Nina Gunde Cimerman
    Nataša Poklar Ulrih
  WP4: Protein Bank: Production and storage of proteins  
  Protein Data Bank: Overview Dušan Turk
12:35 – 13:20 Lunch break  
13:20 – 14:20 5 minutes presentations of scientific work in 2011  
  Effect of Clostridium difficile strains with hemolytic activity on the actin cytoskeleton Mateja Zemljič (WP1)
  How does a sales oriented company start its R&D activities? Mateja Štempelj (WP2)
  Lipid signaling molecules attenuate vesicle mobility in cultured rat astrocytes Saša Trkov (WP2)
  Calcium Dynamics of Langerhans´ Islets in Pancreas Tissue Slices Andraž Stožer (WP2)
  Chemistry in alternative reaction media: Effect of physico-chemical parameters and interactions on reactivity and selectivity (presentation of previous research work) Ajda Podgoršek (WP2)
  The mechanism of HAL2 salt tolerance in fungi living in extreme saline environment Metka Lenassi (WP3)
  Identifying genes for the improvement of plant stress tolerance Cene Gostinčar (WP3)
  Technologies and methodologies behind the WP4 – Protein production and structure determination pipeline Marko Mihelič (WP4)
  Automatic protein function prediction Bernard Ženko (WP4)
  Ectopic expression of group X secreted phospholipase A2 induces proliferation of highly invasive and tumorigenic breast cancer cells Toni Petan (WP2)
  Proteomics of Vipera a. ammodytes and Conus consors venoms Adrijana Leonardi (WP2)
  Structural biology of Clostridium difficile virulence factors Aleksandra Usenik (WP1)
14:20 – 14:35 Coffee break  
14:35 -18:00 Presentation of producers and representatives of scientific equipment  
14.35 - 14:50 Bia d.o.o. Petra Draškovič, Malan Štrbec
14:50 - 15:05 LKB Vertriebs GmbH Richard Feike
15:05 - 15:20 Mikro+Polo d.o.o. Tomaž Hočevar
15:20 - 15:35 Mettler Toledo d.o.o. Keith Racman
Closure of the second day: Dušan Turk  


Programme in PDF file